Extracellular matrix remodeling in human disease
نویسندگان
چکیده
منابع مشابه
Extracellular matrix remodeling in hypertensive heart disease.
everal decades ago, the severity of heart failure was gauged ccording to a depression in myocardial contractility, dened as that biochemical property of cardiac muscle that etermines the extent of shortening independent of its nitial length and the load against which it shortens. athematical models were used to derive indices of conractility (1). These theoretical constructs included a conracti...
متن کاملExtracellular Matrix Remodeling in Hypertension
Increases in arterial blood pressure cause cumulative changes in tissue structure and function, resulting ultimately in end-organ damage. One of the pathological hallmarks of hypertensive tissue injury is an increase in tissue fibrosis, which leads to reductions in tissue compliance and function. Fibrosis (or sclerosis) occurs as result of marked changes in the amount and composition of the ext...
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Remodeling of the extracellular matrix is involved in the initiation and progression of a variety of diseases, including cancer1 and vascular pathology.2–6 However, our knowledge of the precise mechanisms that are involved in remodeling processes is still in its infancy. In this issue of Circulation Research, two studies, one by Bunton et al7 and one by Travis et al,8 provide important examples...
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Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the number of fibroblasts is increased either by replication of the resident myocardial fibroblasts, migration and transformation of circulating bone marrow cells, or by transformation of endothelial/epithelial cells into fibroblasts and myofibroblasts. The primary function of fibroblasts is to produce structu...
متن کاملExtracellular matrix degradation and remodeling in development and disease.
The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. ECM dynamics are indispensible during restructuring of tissue architecture. ECM remodeling is an important mechanism whereby cell d...
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ژورنال
عنوان ژورنال: Journal of Microscopy and Ultrastructure
سال: 2018
ISSN: 2213-879X
DOI: 10.4103/jmau.jmau_4_18